Hyperglycemia and free radical imbalance as prognostic factors in acute stroke

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We evaluated 395 patients with acute stroke: diabetes mellitus was diagnosed in 19.5%, hyperglycemia was observed in 41.8% patients on day 1 and in 48.9% on day 2 after admission. Hyperglycemia and diabetes were associated with more severe free radical imbalance and worsened the outcome in stroke patients, decreasing
rehabilitation potential. The increase of malonic dialdehyde (MDA), decrease of antiperoxide plasma activity (APA), hyperglycemia and high leucocyte count are shown to be prognostic factors of adverse outcome (death, severe disability), which should be taken into account during antioxidant therapy. The highest mortality rate, which showed correlation with the size of stroke, was observed in patients with hyperglycemia persisting more than 3 days after stroke onset, and it was 1.8-fold higher than in patients with normoglycemia. Indications for target antioxidant therapy are: blood glucose > 6.6 mmol/l, leucocyte count >9 700, APC level <3, and MDA level >4 μmol/l

About the authors

S. A. Rumyantceva

Russian National Research Medical University named after N.I. Pirogov

Author for correspondence.
Email: silinaekaterina@mail.ru
Russian Federation, Moscow

E. V. Silina

First Moscow State Medical University named after I.M. Sechenov

Email: silinaekaterina@mail.ru
Russian Federation, Moscow

A. S. Orlova

First Moscow State Medical University named after I.M. Sechenov

Email: silinaekaterina@mail.ru
Russian Federation, Moscow

V. A. Orlov

First Moscow State Medical University named after I.M. Sechenov

Email: silinaekaterina@mail.ru
Russian Federation, Moscow

S. B. Bolevich

First Moscow State Medical University named after I.M. Sechenov

Email: silinaekaterina@mail.ru
Russian Federation, Moscow


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Copyright (c) 2012 Rumyantceva S.A., Silina E.V., Orlova A.S., Orlov V.A., Bolevich S.B.

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