Guillain-Barre syndrome: recovery patterns in demyelinating and axonal forms

Cover Page


Cite item

Full Text

Abstract

We carried out an examination of 74 patients who have had, from 3 months to 36 years ago, Guillain–Barre syndrome (GBS) with severe impairmenet of motor functions. The average follow-up period was 2.3 years. Fifty-eight subjects had acute inflammatory demyelinating polyneuropathy (AIDP), and the remaining 16 patients had axonal forms. In the structure of residual neurologic deficits of AIDP patients at all stages of early recovery period (follow-up period <1 year) and in late (>1 year) period sensory disorders and pain syndrome prevailed. The majority of AIDP patients (90%) began to walk with support after 1 month of onset, and occasionally (3%) six months later.
Patients with axonal forms could stand only after 6 months (88%) and later (12% patients – up to 12 months). After 1 year of onset, all AIDP patients walked unassisted, and most of them return to their job. Over the equal follow-up period every third patient with an axonal form remained dependent in their daily living activities. This confirms that GBS is a disease with a favorable prognosis: even in severe cases most patients resumed walking after half a year, regardless of the disease form. Axonal forms show lower recovery rate and greater severity of residual symptoms compared to AIDP, which affects quality of life in respective patients.

About the authors

D. A. Grishinа

Research Center of Neurology

Author for correspondence.
Email: Grishina82@gmail.com
Russian Federation, Moscow

Natalia A. Suponeva

Research Center of Neurology

Email: Grishina82@gmail.com
ORCID iD: 0000-0003-3956-6362

D. Sci. (Med.), Professor, Corresponding Member of the Russian Academy of Sciences, Head, Neurorehabilitation department with TMS group

Russian Federation, 125367, Russia, Moscow, Volokolamskoye shosse, 80

Michail A. Piradov

Research Center of Neurology

Email: Grishina82@gmail.com
ORCID iD: 0000-0002-6338-0392

D. Sci. (Med.), Professor, Academician of the Russian Academy of Sciences, Director

Russian Federation, 125367, Russia, Moscow, Volokolamskoye shosse, 80

References

  1. Баженов С.А. Качество жизни населения: теория и практика. М.: ЭКОС, 2002.
  2. Гехт Б.М., Никитин С.С. Механизмы компенсаторной реиннервации при повреждении аксона периферических нервов. Журн. неврол. и психиатрии им. С.С. Корсакова 1986; 2: 294–300.
  3. Гехт Б.М., Касаткина Л.Ф., Самойлов М.И., Санадзе А.Г. Электромиография в диагностике нервно-мышечных заболеваний. Таганрог: ТРТУ, 1997.
  4. Пирадов М.А. Синдром Гийена-Барре. М.: Интермедика, 2003.
  5. Пирадов М.А., Супонева Н.А. Синдром Гийена-Барре: современная диагностика и тактика лечения. В сб.: Труды Нац. кон- гресса «Неотложные состояния в неврологии» (под ред. З.А. Суслиной, М.А. Пирадова). М., 2009: 190–196.
  6. Пирадов М.А., Супонева Н.А. Синдром Гийена-Барре: современное состояние проблемы. В сб.: I Нац. конф. с межд. участием «Нейроинфекции». М., 2007: 99–102.
  7. Пирадов М.А., Супонева Н.А. Синдром Гийена-Барре: диагностика и лечение. Руководство для врачей. М: Медпресс, 2011.
  8. Супонева Н.А., Никитин С.С., Пирадов М.А. Воспалительные полиневропатии: проблемная ситуация в России. Современные наукоемкие технологии 2010; 2: 114–115.
  9. Супонева Н.А., Пирадов М.А., Никитин С.С., Павлов Э.В. Анализ причин острого вялого тетрапареза на примере москов- ской популяции. В сб.: Труды Нац. конгресса «Неотложные состояния в неврологии» (под ред. З.А. Суслиной, М.А. Пирадова). М., 2009: 345.
  10. Супонева Н.А. Лечение тяжелых полиневропатий. В сб.: Труды II Нац. конгресса «Неотложные состояния в неврологии» (под ред. З.А. Суслиной, М.А. Пирадова). М., 2011: 86–91.
  11. Bernsen R.A., Jager A.E., Schmitz P.I. et al. Long-term sensory deficit after Guillain-Barré syndrome. Neurology 2001; 248: 483–486.
  12. Bernsen R.A., Jager A.E., Meché F.G. et al. How Guillain-Barre patients experience their functioning after 1 year. Acta Neurol. Scand. 2005; 112: 51–56.
  13. Bernsen R.A., Jacobs H.M., Jager A.E. Residual health status after Guillain-Barre syndrome. J. Neurol. Neurosurg. Psychiatry 1997; 62: 637–640.
  14. Bersano A., Carpo M., Allaria S. et al. Long term disability and social status change after Guillain-Barré syndrome. Neurology 2006; 253: 214–218.
  15. Chio A., Cocito D., Leone M. et al. Guillain-Barre syndrome: a prospective, population-based incidence and outcome survey. Neurology 2003; 60: 1146–1150.
  16. Dorrnonville de la Cour C., Jakobsen J. Residual neuropathy in londterm population-based follow-up of Guillain-Barre syndrome. Neurology 2005; 64: 246–253.
  17. Forsberg A., Press R., Einarsson U. et al. Disability and health-related quality of life in Guillain-Barré syndrome during the first two years after onset: a prospective study. Clin. Rehabil. 2005; 19: 900–909.
  18. Hadden R.D., Cornblath D.R., Hughes R.A. et al. Electrophysiological classification of Guillain-Barre syndrome: clinical association and outcome. Ann. Neurol. 1998; 44: 780–788.
  19. Hadden R.D. Preceding infection, immune factors and outcome in Guillain-Barre syndrome. Neurology 2001, 56: 758–765.
  20. Hiraga A., Mori M., Ogawara K. et al. Recovery patterns and long term prognosis for axonal Guillain-Barre syndrome. J. Neurol. Neurosurg. Psychiatry 2005; 76: 719–722.
  21. Ho T.W., Li C.Y., Cornblath D.R. et al. Patterns of recovery in the Guillain-Barre syndrome. Neurology 1997; 48: 695–700.
  22. Hughes R.A., Hadden R.D., Rees J.H., Swan A.V. The prognosis and main prognostic indicators of Guillain-Barré syndrome. A multicentre prospective study of 297 patients. The Italian Guillain-Barre Study Group. Brain 1996; 119: 2053–2061.
  23. Jager A.E., Minderhoud J.M. Residual signs in severe Guillain-Barré syndrome: analysis of 57 patients. Neurol. Sci. 1991; 104: 151–156.
  24. Koeppen S., Kraywinkel K., Wessendorf T.E. et al. Long-term outcome of Guillain-Barré syndrome. Neurocrit. Care 2006; 5: 235–242.
  25. Koningsveld R., Steyerberg E.W., Hughes R.A. et al. A clinical prognostic scoring system for Guillain-Barre syndrome. Lancet Neurol. 2007; 6: 589–594.
  26. Tamura N., Kuwabara S., Misawa S. Time course of axonal regeneration in acute motor axonal neuropathy. Muscle Nerve 2007; 35: 793–795

Supplementary files

Supplementary Files
Action
1. JATS XML

Copyright (c) 2012 Grishinа D.A., Suponeva N.A., Piradov M.A.

Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.

СМИ зарегистрировано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор).
Регистрационный номер и дата принятия решения о регистрации СМИ: серия ПИ № ФС 77-83204 от 12.05.2022.


This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies