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Creutzfeldt-Jakob disease (CJD) is a form of human prion diseases, fatal neurodegenerative conditions. They can be etiologically divided into sporadic, hereditary and acquired forms. Conformational change of the normal (cellular) form of prion protein (PrPc) to a pathological form (PrPSс) is a central event in the formation of an infectious agent. In this article, diagnostic criteria for sporadic CJD are summarized. Case report of probable sporadic CJD is presented. Many therapeutic strategies (based on cell cultures or animals) have been tested as potential treatments for prion diseases. However, only few clinical trials are in progress now or have been completed.
Sporadic Creutzfeldt-Jakob disease: clinical observation
- Authors: Peresedova A.V.1, Stoida N.I.1, Gnezditskiy V.V.1, Konovalov R.N.1, Korepina O.S.1, Zavalishin I.A.1
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Affiliations:
- Research Center of Neurology
- Issue: Vol 5, No 4 (2011)
- Pages: 52-56
- Section: Clinical analysis
- URL: https://annaly-nevrologii.com/journal/pathID/article/view/288
- DOI: https://doi.org/10.17816/psaic288
- ID: 288
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About the authors
A. V. Peresedova
Research Center of Neurology
Email: a.v.pesedova@mail.ru
Russian Federation, Moscow
N. I. Stoida
Research Center of Neurology
Email: a.v.pesedova@mail.ru
Russian Federation, Моscow
V. V. Gnezditskiy
Research Center of Neurology
Email: a.v.pesedova@mail.ru
Russian Federation, Moscow
Rodion N. Konovalov
Research Center of Neurology
Email: a.v.pesedova@mail.ru
ORCID iD: 0000-0001-5539-245X
Cand. Sci. (Med.), senior researcher, Neuroradiology department
Russian Federation, 125367 Moscow, Volokolamskoye shosse, 80Olga S. Korepina
Research Center of Neurology
Email: a.v.pesedova@mail.ru
Russian Federation, Moscow
I. A. Zavalishin
Research Center of Neurology
Author for correspondence.
Email: a.v.pesedova@mail.ru
Russian Federation, Moscow
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