Sporadic Creutzfeldt-Jakob disease: clinical observation

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Creutzfeldt-Jakob disease (CJD) is a form of human prion diseases, fatal neurodegenerative conditions. They can be etiologically divided into sporadic, hereditary and acquired forms. Conformational change of the normal (cellular) form of prion protein (PrPc) to a pathological form (PrPSс) is a central event in the formation of an infectious agent. In this article, diagnostic criteria for sporadic CJD are summarized. Case report of probable sporadic CJD is presented. Many therapeutic strategies (based on cell cultures or animals) have been tested as potential treatments for prion diseases. However, only few clinical trials are in progress now or have been completed.


About the authors

A. V. Peresedova

Research Center of Neurology

Email: a.v.pesedova@mail.ru
Russian Federation, Moscow

N. I. Stoida

Research Center of Neurology

Email: a.v.pesedova@mail.ru
Russian Federation, Моscow

V. V. Gnezditskiy

Research Center of Neurology

Email: a.v.pesedova@mail.ru
Russian Federation, Moscow

Rodion N. Konovalov

Research Center of Neurology

Email: a.v.pesedova@mail.ru
ORCID iD: 0000-0001-5539-245X

Cand. Sci. (Med.), senior researcher, Neuroradiology department

Russian Federation, 125367 Moscow, Volokolamskoye shosse, 80

Olga S. Korepina

Research Center of Neurology

Email: a.v.pesedova@mail.ru
Russian Federation, Moscow

I. A. Zavalishin

Research Center of Neurology

Author for correspondence.
Email: a.v.pesedova@mail.ru
Russian Federation, Moscow


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Copyright (c) 2011 Peresedova A.V., Stoida N.I., Gnezdizky V.V., Konоvаlоv R.N., Kоrеpina O.S., Zavalishin I.A.

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