Antiparkinsonian effect of dicholine succinate on the model of MPTP-induced parkinsonism

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Antiparkinsonian effects of dicholine succinate (intranasal application of 0.2–5.0 mg/kg) was studied in the C57Bl/6 mice model of parkinsonism caused by a single i.p. injection of 25 mg/kg 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). Dicholine succinate was found to be characterized by significant antiparkinsonian effects, as indicated by reduction of akinesia in the “open field” test horizontal locomotor activity (0.2, 1.0 and 5.0 mg/kg) and reduction of muscle rigidity assessed through the step length (1.0 and 5.0 mg/kg). However, dicholine succinate did not exhibit any effect on such major MPTP-induced parkinsonian symptoms as tremor, piloerection, latero- and retropulsion.


About the authors

A. K. Sariev

Research Center of Neurology, Russian Academy of Medical Sciences

Russian Federation, Moscow

V. M. Rychikhin

Research Center of Neurology, Russian Academy of Medical Sciences

Russian Federation, Moscow

I. A. Pomytkin

Biosignal, Ltd

Russian Federation, Moscow

T. A. Voronina

Research Institute of Pharmacology, Russian Academy of Medical Sciences

Author for correspondence.
Russian Federation, Moscow


  1. Воронина Т.А., Вальдман Е.А., Неробкова Л.Н. Методические указания по изучению антипаркинсонической активности фармакологических веществ, Руководство по экспериментальному (доклиническому) изучению новых фармакологических веществ. М., 2005: 295–307.
  2. Gerlach M., Riederer P. Animal models of Parkinson’s sdisease: An empirical comparison with the phenomenology of the disease in man. J. Neural Transm. 1996; 103: 987–1041.
  3. German D.C., Nelson E.L., Liang С.L. et al. The neurotoxin MPTP causes degeneration of specific nucleus A8, A9 and A10 dopaminergic neurons in the mouse. Neurodegeneration 1996; 5: 299–312.
  4. Schapira A.H.V. Progress in neuroprotection in Parkinson’s disease. Eur. J. Neurol. 2008; 15 (Suppl. 1): 5–13.
  5. Schmidt N., Ferger B. Neurochemical findings in the MPTP model of Parkinson’s disease. J. Neural Transm. 2001; 108: 1263–1282.
  6. Storozheva Z.I., Proshin A.T., Sherstnev V.V. et al. Dicholine salt of succinic acid, a neuronal insulin sensitizer, ameliorates cognitive deficits in rodent models of normal aging, chronic cerebral hypoperfusion, and beta-amyloid peptide-(25-35)-induced amnesia. BMC Pharmacol. 2008; 8: 1.
  7. Storozhevykh T.P., Senilova Y.E., Persiyantseva N.A. et al. Mitochondrial respiratory chain is involved in insulin-stimulated hydrogen peroxide production and plays an integral role in insulin receptor autophosphorylation in neurons. BMC Neurosci. 2007; 8: 84.

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Copyright (c) 2011 Sariev A.K., Rychikhin V.M., Pomytkin I.A., Voronina T.A.

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