Antiparkinsonian effect of dicholine succinate on the model of MPTP-induced parkinsonism

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Abstract

Antiparkinsonian effects of dicholine succinate (intranasal application of 0.2–5.0 mg/kg) was studied in the C57Bl/6 mice model of parkinsonism caused by a single i.p. injection of 25 mg/kg 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). Dicholine succinate was found to be characterized by significant antiparkinsonian effects, as indicated by reduction of akinesia in the “open field” test horizontal locomotor activity (0.2, 1.0 and 5.0 mg/kg) and reduction of muscle rigidity assessed through the step length (1.0 and 5.0 mg/kg). However, dicholine succinate did not exhibit any effect on such major MPTP-induced parkinsonian symptoms as tremor, piloerection, latero- and retropulsion.

 

About the authors

A. K. Sariev

Research Center of Neurology, Russian Academy of Medical Sciences

Author for correspondence.
Email: platonova@neurology.ru
Russian Federation

V. M. Rychikhin

Research Center of Neurology, Russian Academy of Medical Sciences

Email: platonova@neurology.ru
Russian Federation

I. A. Pomytkin

Biosignal, Ltd

Email: platonova@neurology.ru
Russian Federation

T. A. Voronina

Research Institute of Pharmacology, Russian Academy of Medical Sciences (Moscow)

Email: platonova@neurology.ru
Russian Federation

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Copyright (c) 2017 Sariev A.K., Rychikhin V.M., Pomytkin I.A., Voronina T.A.

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