Functional Magnefic Resonance Imaging

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Since the early 1990s, fMRI has come to dominate the brain mapping field due to its relatively low invasiveness, absence of radiation exposure, and relatively wide availability. It measures the hemodynamic response related to neural activity in the brain (BOLD-effect). During planning fMRI experiment it is important to take into account equipment (MRI scan, devices for the stimuli presentation), experimental design and post processing. The last one includes several important steps, such as realignment, co-registration, normalization, smoothing. Nowadays fMRI is widely used not only in research field, especially for cognitive studies, but in clinical practice. However investigator should always remember some limitations and controversies, especially in patients with various nosological forms. It is also important to draw many specialists in experiment and its interpretation — neuroradiologists, MR-physicists, clinicians, psychologists, etc. — while fMRI is multidisciplinary methodic.


About the authors

E. I. Kremneva

Research Center of Neurology, Russian Academy of Medical Sciences (Moscow)

Author for correspondence.
Russian Federation

R. N. Konovalov

Research Center of Neurology, Russian Academy of Medical Sciences (Moscow)

Russian Federation

M. V. Krotenkova

Research Center of Neurology, Russian Academy of Medical Sciences (Moscow)

Russian Federation


  1. Ashburner J., Friston K. Multimodal image coregistration and partitioning – a unified framework. NeuroImage 1997; 6 (3): 209–217.
  2. Brian N. Pasley, Ralph D. Freeman. Neurovascular coupling. Scholarpedia 2008; 3 (3): 5340.
  3. Chen C.M., Hou B.L., Holodny A.I. Effect of age and tumor grade on BOLD functional MR imaging in preoperative assessment of patients with glioma. Radiology 2008; 3: 971–978.
  4. Filippi M. fMRI techniques and protocols. Humana press 2009: 25.
  5. Friston K.J., Williams S., Howard R. et al. Movement-related effects in fMRI time-series. Magn. Reson. Med. 1996; 35: 346–355.
  6. Glover, G.H., Lai S. Self-navigated spiral fMRI: Interleaved versus single-shot. Magn. Reson. Med. 1998; 39: 361–368.
  7. Haller S., Bartsch A.J. Pitfalls in fMRI. Eur. Radiol. 2009; 19: 2689–2706.
  8. Hsu Y.Y., Chang C.N., Jung S.M. et al. Blood oxygenation leveldependent MRI of cerebral gliomas during breath holding. J. Magn. Reson Imaging 2004; 2: 160–167.
  9. Huettel S.A., Song A.W., McCarthy G. Functional magnetic resonance imaging. Sinauer Associates, Inc. 2004: 295–317.
  10. Ogawa S., Lee T.M. Magnetic resonance imaging of blood vessels at high fields: In vivo and in vitro measurements and image simulation. Magn. Reson. Med. 1990; 16 (1): 9–18.
  11. Practice guideline for the performance of functional magnetic resonance imaging of the brain (fMRI). ACR practice guideline. American College of Radiology 2007; 3: 153–156.
  12. Talairach J., Tournoux P. Co-planar Stereotaxic Atlas of the Human Brain: 3-Dimensional Proportional System — an Approach to Cerebral Imaging. Thieme Medical Publishers. New York: 1988.



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Copyright (c) 2017 Kremneva E.I., Konovalov R.N., Krotenkova M.V.

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