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Chronic alcohol myopathy (CAM) is one of frequent manifestations of the alcoholic disease, but its pathogenesis remains to be elucidated. Main mechanism of the CAM development is suggested to be abnormalities of protein synthesis in muscle fibers. A complex clinical, morphological and biochemical investigation of 38 patients with chronic alcohol intoxication was performed. Clinical manifestations of skeletal muscle damage corresponded to severity of the atrophic process assessed by histological studies of muscle biopsies. Disturbances of main stages of protein synthesis both on intracellular and on systemic regulatory level was revealed.
Mechanisms of the development of skeletal muscle atrophy in chronic alcohol intoxication
- Authors: Kazantseva Y.V.1, Maslova G.V.1, Lysenko E.A.2, Zinovyeva O.E.1, Shenkman B.S.2, Yakhno N.N.1
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Affiliations:
- 1st Moscow State Medical University named after I.M. Sechenov
- Institute of Medico-Biological Problems, Russian Academy of Sciences
- Issue: Vol 4, No 4 (2010)
- Pages: 15-19
- Section: Original articles
- URL: https://annaly-nevrologii.com/journal/pathID/article/view/327
- DOI: https://doi.org/10.17816/psaic327
- ID: 327
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Abstract
About the authors
Yu. V. Kazantseva
1st Moscow State Medical University named after I.M. Sechenov
Email: zinovyevaolga@yandex.ru
Russian Federation, Moscow
G. V. Maslova
1st Moscow State Medical University named after I.M. Sechenov
Email: zinovyevaolga@yandex.ru
Russian Federation, Moscow
E. A. Lysenko
Institute of Medico-Biological Problems, Russian Academy of Sciences
Email: zinovyevaolga@yandex.ru
Russian Federation, Moscow
O. E. Zinovyeva
1st Moscow State Medical University named after I.M. Sechenov
Author for correspondence.
Email: zinovyevaolga@yandex.ru
Russian Federation, Moscow
B. S. Shenkman
Institute of Medico-Biological Problems, Russian Academy of Sciences
Email: zinovyevaolga@yandex.ru
Russian Federation, Moscow
N. N. Yakhno
1st Moscow State Medical University named after I.M. Sechenov
Email: zinovyevaolga@yandex.ru
Russian Federation, Moscow
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СМИ зарегистрировано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор).