Mechanisms of the development of skeletal muscle atrophy in chronic alcohol intoxication

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Abstract

Chronic alcohol myopathy (CAM) is one of frequent manifestations of the alcoholic disease, but its pathogenesis remains to be elucidated. Main mechanism of the CAM development is suggested to be abnormalities of protein synthesis in muscle fibers. A complex clinical, morphological and biochemical investigation of 38 patients with chronic alcohol intoxication was performed. Clinical manifestations of skeletal muscle damage corresponded to severity of the atrophic process assessed by histological studies of muscle biopsies. Disturbances of main stages of protein synthesis both on intracellular and on systemic regulatory level was revealed.

 

About the authors

Yu. V. Kazantseva

1st Moscow State Medical University named after I.M. Sechenov

Author for correspondence.
Email: platonova@neurology.ru
Russian Federation

G. V. Maslova

1st Moscow State Medical University named after I.M. Sechenov

Email: platonova@neurology.ru
Russian Federation

E. A. Lysenko

Institute of Medico-Biological Problems, Russian Academy of Sciences (Moscow)

Email: platonova@neurology.ru
Russian Federation

O. E. Zinovyeva

1st Moscow State Medical University named after I.M. Sechenov

Email: platonova@neurology.ru
Russian Federation

B. S. Shenkman

Institute of Medico-Biological Problems, Russian Academy of Sciences (Moscow)

Email: platonova@neurology.ru
Russian Federation

N. N. Yakhno

1st Moscow State Medical University named after I.M. Sechenov

Email: platonova@neurology.ru
Russian Federation

References

  1. Estruch R., Sacanella E., Fernandez-Sola J. et al. Natural history of alcoholic myopathy: 5-year study. Alcoholism: Clin. Exp. Res. 1998; 22: 2023–2028.
  2. Fernandez-Sola J., Sacanella E., Estruch R. et al. Serum and muscle levels of alpha-tocopherol, ascorbic acid, and retinol are normal in chronic alcoholic myopathy. Alcoholism: Clin Exp. Res. 1998; 22: 422–427. 3. Ferraz M.L., Gabbai A.A., Oliveira A.S. et al. Histochemical study of the skeletal muscle in chronic alcoholism. Arq. Neuropsiquiatr. 1989; 47: 139–149.
  3. Kumar V., Frost R.A., Lang C.H. Alcohol impairs insulin and IGFI stimulation of S6K1 but not 4E-BP1 in skeletal muscle. Am. J. Physiol. Endocrinol. Metab. 2002; 283: 917–928.
  4. Lang C.H., Frost R.A. Role of growth hormone, insulin-like growth factor-I, and insulin-like growth factor binding proteins in the catabolic response to injury and infection. Anabolic and catabolic signals. Curr. Opin. Clin. Nutrition & Metab. Care 2002; 15: 271–279.
  5. Lang C.H., Frost R.A., Deshpande N. et al. Alcohol impairs leucinemediated phosphorylation of 4E-BP1, S6K1, eIF4G, and mTOR in skeletal muscle. Am. J. Physiol. Endocrinol. Metab. 2003; 285: 1205–1215.
  6. Lang С.Н., Frost R.A., Svanberg Е., Vary T.C. IGF-I/IGFBP-3 ameliorates alterations in protein synthesis, eIF4E availability, and myostatin in alcohol-fed rats. Am. J. Physiol. Endocrinol. Metab. 2004; 286: 916–926.
  7. Mills K.R., Ward K., Martin F., Paters T.J. Peripheral neuropathy and myopathy in chronic alcoholism. Alcohol and Alcoholism 1986; 21: 357–362.
  8. Nicolas J.M., Garcia G., Fatjo F. et al. Influence of nutritional status on alcoholic myopathy. Am. J. Clin. Nutr. 2003; 78: 326–333.
  9. Powers T. TOR signaling and S6 kinase 1: Yeast catches up. Cell Metab. 2007; 6: 1–2.
  10. Preedy V.R., Adachi J., Ueno Y. et al. Alcoholic skeletal muscle myopathy: definitions, features, contribution of neuropathy, impact and diagnosis. Eur. J. Neurol. 2001; 8: 677–687.
  11. Preedy V.R., Ohlendieck K., Adachi J. et al. The importance of alcohol- induced muscle disease. J. Muscle Res. Cell Motil. 2003; 24: 55–63.
  12. Reilly M.E., Erylmaz E.I., Amir A. et al. Skeletal muscle ribonuclease activities in chronically ethanol treated rats. Alcoholism: Clin. Exp. Res. 1998; 22: 876–883.
  13. Sharma S.C., Ray R.C., Banerjee A.K., Lakshmanan C. Chronic muscle wasting in alcoholics — a histochemical and biochemical study. Indian J. Pathol. Microbiol. 1990; 33: 244–249.
  14. Staron R.S., Hagerman F.C., Hikida R.S. et al. Fiber type composition of the vastus lateralis muscle of young men and women. J. Histochem. Cytochem. 2000; 48: 623–629.
  15. Vargas R., Lang C.H. Alcohol accelerates loss of muscle and impairs recovery of muscle mass resulting from disuse atrophy. Alcoholism: Clin. Exp. Res. 2008; 32: 128–137.
  16. Vary T.C., Lynch C.J. Nutrient signaling components controlling protein synthesis in striated muscle. J. Nutr. 2007; 137: 1835–1843.

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Copyright (c) 2017 Kazantseva Y.V., Maslova G.V., Lysenko E.A., Zinovyeva O.E., Shenkman B.S., Yakhno N.N.

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