Прижизненная оценка накопления β-амилоида в головном мозге человека

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Abstract

Болезнь Альцгеймера (БА) является основной причиной первичной деменции, и необходимость в эффективной терапии БА чрезвычайно велика. Накопление β амилоида (Aβ) в мозге представляет собой хорошо известный специфический признак БА. Однако растущее число работ показывает, что патологическое накопление Aβ может иметь место задолго до клинической манифестации БА. Сегодня доступны технологии визуализации Ab, имеющие значительный потенциал с точки зрения количественной оценки патологии Aβ, ассоциированной со старением и БА. В настоящее время наиболее надежной технологией визуализации патологии Ab в мозге человека in vivo является позитронно-эмиссионная томография (ПЭТ) с радиофармпрепаратом [11C] PIB. Этот метод продемонстрировал значительное накопление Aβ у больных БА и при умеренных когнитивных расстройствах. Наиболее серьезным наблюдением стал тот факт, что некоторые пожилые лица с сохранными когнитивными функциями имеют повышенное связывание [11C] PIB, что может указывать на преклиническую стадию БА. Требуется дальнейшее накопление данных для демонстрации временнoго паттерна накопления бляшек Aβ в мозге, что должно существенно улучшить наши знания о природе БА и помочь предложить более совершенные терапевтические подходы.

About the authors

А. Г. Власенко

Department of Radiology, University of Washington School of Medicine

Author for correspondence.
Email: platonova@neurology.ru
США, St.Luis

М. А. Минтон

Department of Radiology, University of Washington School of Medicine

Email: platonova@neurology.ru
США, St. Luis

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