Multiple sclerosis: current state

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Abstract

Etiology of multiple sclerosis has both genetic and environmental components. The current conception is that multiple sclerosis pathogenesis comprises an initial inflammatory phase, followed by a phase of demyelination and last, a neurodegenerative phase. The mechanisms of inflammatory reactions, axonal loss and reparative changes have been discussed. There are two schemes of treatments: the escalating approach and the induction therapy. One of the main principles of disease modifying therapy of MS is treat-early approach. Results of interferon’s-b and glatiramer acetate comparison as first-line MS therapy have been described. The use immunosuppressive agents and future developments of MS therapy have been discussed.

 
 

About the authors

A. V. Peresedova

Research Center of Neurology

Email: a.v.pesedova@mail.ru
Россия, Moscow

I. A. Zavalishin

Research Center of Neurology

Author for correspondence.
Email: a.v.pesedova@mail.ru
Россия, Moscow

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Copyright (c) 2009 Peresedova A.V., Zavalishin I.A.

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