Epidemiology of parkinsonism in the Krasnoyarsk region

The authors present a 5-year experience of register of parkinsonism in the Krasnoyarsk region. The register comprises 826 patients with different forms of parkinsonism. The great majority of the revealed cases (79,1%) falls into Parkinson’s disease (PD), more rare are vascular (11,3%) and neuroleptic parkinsonism (2,1%), as well as neurodegenerative syndromes from the group of «parkinsonism-plus» (2,9% in total). The prevalence of PD in the Krasnoyarsk city is 62.72 per 100 000 in general population and 261.25 per 100 000 in the population above 65 years of age, that corresponds to the data in other populations; at the same time, lower figures in the Krasnoyarsk region (22.57 per 100 000 in general population and 100.32 per 100 000 in the population above 65 years of age) suggest, most probably, low detectability of this condition in primary care hospitals of the region. We detected earlier debut of PD in patients working in chemical industry (62,27±5,69 years), as well as in veterinaries and cattlemen (57,54±4,91), which may serve as confirmation of the discussed in the literature connection between PD and some neurotoxins used in the agriculture. High prevalence of cognitive disturbances of various severity in PD was registered (79,2% patients in total), and higher frequency and severity of cognitive decline was seen in an akineticrigid form of the disease.