The main pathogenetic mechanisms of vascular cerebral pathology associated with atherosclerosis and metabolic syndrome: the search for correction approaches

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Metabolic syndrome (MS) is a risk factor for the development of acute and chronic vascular diseases of the brain. Oxidative stress developing under these conditions promotes the progression of atherosclerotic disease of the brachiocephalic arteries, which necessitates correction of the identified pathobiochemical abnormalities. The use of antioxidant drugs in patients with cerebrovascular diseases and MS reduces manifestations of the latter, including insulin resistance, hypertriglyceridemia, and hyperglycemia. The article presents the results of investigation of the drug mexidol in patients with chronic cerebrovascular diseases associated with atherosclerosis and MS. The findings demonstrate that drugs of this group have good prospects to be used for comprehensive correction of various pathogenic stages of the developing pathology.

About the authors

M. M. Tanashyan

Research Center of Neurology, Moscow

Author for correspondence.
Russian Federation

O. V. Lagoda

Research Center of Neurology, Moscow

Russian Federation

K. V. Antonova

Research Center of Neurology, Moscow

Russian Federation

A. A. Raskurazhev

Research Center of Neurology, Moscow

Russian Federation


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Copyright (c) 2016 Tanashyan M.M., Lagoda O.V., Antonova K.V., Raskurazhev A.A.

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