The role of personality disorders in the management of patients with pharmacoresistant epilepsy after neurosurgical resections

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Abstract

The review focuses on the problem of personality disorders that arise in patients with pharmaco-resistant epilepsy after neurosurgical resections. We analyzed 47 research articles, selected by keywords from Russian and international databases for 2010–2017. It was found that, despite the achievements in epilepsy surgery and the high percentage of remission in the postoperative period, the problem of personality disorders remains important. The most frequent postoperative personality disorders are anxiety and depression, which greatly exacerbate the course of the postoperative period and make it difficult for the patient to adapt in society because of his internal stigmatization. In addition, depression can provoke the aggravation of epileptic seizures in the postoperative period. Psychiatric anamnesis and a severe form of depression in the preoperative period are the powerful predictors of the depression onset in the postoperative period. Despite this, there are no psychiatric contraindications to the surgical treatment of pharmaco-resistant epilepsy. The authors discuss the need for perioperative psychiatric testing of patients suffering from epilepsy.

About the authors

Ekaterina A. Narodova

Prof. V.F. Voino-Yasenetsky Krasnoyarsk State Medical University

Author for correspondence.
Email: katya_n2001@mail.ru
Россия, Krasnoyarsk

Natalia A. Schneider

V.M. Bekhterev National Medical Research Center for Psychiatry and Neurology

Email: katya_n2001@mail.ru
Россия, St. Petersburg

Andrey A. Narodov

Prof. V.F. Voino-Yasenetsky Krasnoyarsk State Medical University

Email: katya_n2001@mail.ru
Россия, Krasnoyarsk

Diana V. Dmitrenko

Prof. V.F. Voino-Yasenetsky Krasnoyarsk State Medical University

Email: katya_n2001@mail.ru
Россия, Krasnoyarsk

Irina G. Strotskaya

Prof. V.F. Voino-Yasenetsky Krasnoyarsk State Medical University

Email: katya_n2001@mail.ru
Россия, Krasnoyarsk

Polina V. Moskaleva

Prof. V.F. Voino-Yasenetsky Krasnoyarsk State Medical University

Email: katya_n2001@mail.ru
Россия, Krasnoyarsk

References

  1. Berg A.T. Epidemiology of epilepsies: Overview. In: Panayiotopoulos C.P. (ed.) Atlas of Epilepsis. L.; 2010: 45–49.
  2. Gutierrez-Galve L., Flugel D., Thompson P.J. et al. Cortical abnormalities and their cognitive correlates in patients with temporal lobe epilepsy and interictal psychosis. Epilepsia 2012; 53: 1077–1087. doi: 10.1111/j.1528-1167.2012.03504. PMID: 22578165.
  3. Kanner A.M., Barry J.J., Gilliam F. et al. Depressive and anxiety disorders in epilepsy: do they differ in their potential to worsen common antiepileptic drug-related adverse events? Epilepsia 2012; 53: 1104–1108. doi: 10.1111/j.1528-1167.2012.03488.x. PMID: 22554067.
  4. Mukhin K.Yu., Petrukhin A.S., Kholin A.A. Epilepticheskiye entsefalopatii [Epileptic encephalopathies]. Мoscow; 2011. (In Russ.)
  5. Baker G.A., Taylor J., Aldenkamp A.P., SANAD group. Newly diagnosed epilepsy: cognitive outcome after 12 months. Epilepsia 2011; 52: 1084–1091. doi: 10.1111/j.1528-1167.2011.03043.x. PMID: 21453356.
  6. Liu S.Y., Yang X.L., Chen B. et al. Clinical outcomes and quality of life following surgical treatment for refractory epilepsy: a systematic review and meta-analysis. Medicine (Baltimore) 2015; 94: e500. doi: 10.1097/MD.0000000000000500. PMID: 25674741.
  7. Avakyan G.P., Aksenova M.G., Badalyan O.L. et al. [Ineffectiveness of antiepileptic therapy. The main reasons and possible ways to overcome it]. Zhurnal nevrologii i psikhiatrii im. S.S. Korsakova 2008; 108(2; pril. Epilepsiya): 40–42. (In Russ.)
  8. Bochanova E.N. [Pharmacogenetics of antiepileptic drugs (literature review)]. Kachestvennaya klinicheskaya praktika 2017; (1): 51–55. (In Russ.)
  9. Bochanova E.N., Schneider N.A., Zyryanov S.K. et al. [Age and gender aspects of unwanted adverse reactions in patients with epilepsy and epileptic syndromes (according to the register of the University clinic)]. Farmateka 2016; (7): 71–75. (In Russ.)
  10. Gekht A.B., Milchakova L.E., Churilin Yu.Yu. [Epidemiology of epilepsy in Russia]. Zhurnal nevrologii i psikhiatrii im. S.S. Korsakova 2006; (1; pril. Epilepsiya): 3–7. (In Russ.)
  11. Belousova E.D. [Influence of antiepileptic drugs on cognitive functions: in focus – perampanel]. Epilepsiya i paroksizmal'nyye sostoyaniya 2016; 8(3): 6–10. (In Russ.)
  12. Mula M. [Depression and epilepsy: epidemiological and neurobiological aspects]. In: Sovremennaya epileptologiya: problemy i resheniya. [Modern epileptology: problems and solutions]. Мoscow; 2015: 117–122. (In Russ.)
  13. Trimble M. Treatment issues for personality disorders in epilepsy. Epilepsia 2013; 54(suppl1): S41–S45. doi: 10.1111/epi.12104. PMID: 23458465.
  14. Dudra-Jastrzebska M., Andres-Mach M.M., Łuszczki J.J., Czuczwar S.J. Mood disorders in patients with epilepsy. Pharmacol Rep 2007; 59: 369–378. PMID: 17901565.
  15. Kimiskidis V.K., Triantafyllou N.I., Kararizou E. et al. Depression and anxiety in epilepsy: the association with demographic and seizure-related variables. Ann Gen Psychiatry 2007; 6: 28. doi: 10.1186/1744-859X-6-28. PMID: 17971199.
  16. Dmitrenko D.V., Schneider N.A., Govorina Yu.B. et al. The level of depression and anxiety in women of reproductive age, suffering from epilepsy. Izvestiya Samarskogo nauchnogo tsentra Rossiyskoy akademii nauk 2014; 16(5–4): 1273–1276. (In Russ.)
  17. Koh S., Magid R., Chung H. et al. Depressive behavior and selective down-regulation of serotonin receptor expression after early-life seizures: reversal by environmental enrichment. Epilepsy Behav Behavior 2007; 10: 26–31. doi: 10.1016/j.yebeh.2006.11.008. PMID: 17196883.
  18. Kissin M.Ya. Klinicheskaya epileptologiya [Clinical epileptology]. Мoscow; 2009. (In Russ.)
  19. Vorobyova O.V., Skripkin A.Yu. [Depression in patients with epilepsy (features of phenomenology and approaches to treatment)]. Lechebnoye delo 2010; (2): 96–104. (In Russ.)
  20. Zheleznova E.V., Medvedev I.L. [Risk factors for depression in women with epilepsy]. Sotsial'naya i klinicheskaya psikhiatriya 2010; 20(4): 21–25. (In Russ.)
  21. Kuzminova M.V. [Depressive, anxious and obsessive-phobic disorders in patients with epilepsy]. Sovremennaya terapiya v psikhiatrii i nevrologii 2014; (1): 23–25. (In Russ.)
  22. Krivtsova A.Yu., Zhadnov V.A., Erkhova L.N. [Features of the psychological portrait of patients with epilepsy with the presence and absence of a group of disabilities]. Lichnost' v menyayushchemsya mire: zdorov'ye, adaptatsiya, razvitiye 2014; (3): 76–83. (In Russ.)
  23. Grigoryeva I.V., Dokukina T.V., Makhrov M.M., Khlebokazov F.P. [The main psychotherapeutic tasks in the process of destigmatization of patients with epilepsy]. Epilepsiya i paroksizmal'nyye sostoyaniya 2013; 5(4): 10–12. (In Russ.)
  24. Tyumenkova G.V., Portnova A.A., Kekelidze Z.I. [Stigma and discrimination of epileptic patients]. Rossiyskiy psikhiatricheskiy zhurnal 2005; (4): 51–57. (In Russ.)
  25. Baskind R., Birbeck G.L. Epilepsy-associated stigma in sub-Saharan Africa: The social landscape of a disease. Epilepsy Behav 2005; 7: 68–73. doi: 10.1016/j.yebeh.2005.04.009. PMID: 15978874.
  26. Mikhailov V.A. [Topical issues of epileptology are stigmatization, quality of life and rehabilitation of patients]. Epilepsiya i paroksizmal'nyye sostoyaniya 2010; 2(3): 39–44. (In Russ.)
  27. Melikyan E.G., Gekht A.B. [Quality of life of patients with epilepsy]. Lechebnoye delo 2011; (1): 1–9. (In Russ.)
  28. Lebedeva A.V., Melikyan E.G., Gekht A.B. [Therapy of depression in patients with focal epilepsy (experience with citalopram)]. Nevrologiya, neyropsikhiatriya, psikhosomatika 2011; (2): 50–56. (In Russ.)
  29. Карлов В.А. Karlov V.A. Epilepsiya u detey i vzroslykh zhenshchin i muzhchin [Epilepsy in children and adult women and men]. Мoscow; 2010. (In Russ.)
  30. Koch-Stoecker S., Schmitz B., Kanner A.M. Treatment of postsurgical psychiatric complications. Epilepsia 2013; 54: 46–52. doi: 10.1111/epi.12105. PMID: 23458466.
  31. American Psychiatric Association. Diagnostic and statistical manual of mental disorders. Washington; 2013.
  32. Hellwig S., Mamalis P., Feige B. et al. Psychiatric comorbidity in patients with pharmacoresistant focal epilepsy and psychiatric outcome after epilepsy surgery. Epilepsy Behav 2012; 23: 272–279. doi: 10.1016/j.yebeh.2011.12.001. PMID: 22341961.
  33. Lebedeva A.V., Melikyan E.G., Stepanenko A.Yu. et al. [The dynamics of quality of life in patients with pharmacoresistant epilepsy in surgical methods of treatment]. Vestnik Natsional'nogo mediko-khirurgicheskogo tsentra im. N.I. Pirogova 2011; 6(3): 67–70. (In Russ.)
  34. Ramos-Perdigués S., Baillés E., Mané A. et al. A prospective study contrasting the psychiatric outcome in drug-resistant epilepsy between patients who underwent surgery and a control group. Epilepsia 2016; 57: 1680–1690. doi: 10.1111/epi.13497. PMID: 27562413.
  35. Kanner A.M. Do psychiatric comorbidities have a negative impact on the course and treatment of seizure disorders. Curr Opin Neurol 2013; 26: 208–213. doi: 10.1097/wco.0b013e32835ee579. PMID: 23429545.
  36. Rheims S., Didelot A., Guenot M. et al. Subcontinuous epileptiform activity after failed hippocampal radiosurgery. Epilepsia 2011; 52: 1425–1429. doi: 10.1111/j.1528-1167.2011.03123.x. PMID: 21668438.
  37. Kerr M.P., Mensah S., Besag F. et al. International consensus clinical practice statements for the treatment of neuropsychiatric conditions associated with epilepsy. Epilepsia 2011; 52: 2133–2138. doi: 10.1111/j.1528-1167.2011.03276.x. PMID: 21955156.
  38. Fazel S., Wolf A., Långström N. et al. Premature mortality in epilepsy and the role of psychiatric comorbidity: a total population study. Lancet 2013; 382: 1646–1654. doi: 10.1016/s0140-6736(13)60899-5. PMID: 23883699.
  39. Hagemann A., May T.W., Nieder E. et al. Quality of life, anxiety and depression in adult patients after add-on of levetiracetam and conversion to levetiracetam monotherapy. Epilepsy Res 2013; 104: 140–150. doi: 10.1016/j.eplepsyres.2012.08.005. PMID: 22959715.
  40. Hedegärd E., Bjellvi J., Edelvik A. et al. Complications to invasive epilepsy surgery workup with subdural and depth electrodes: a prospective population-based observational study. J Neurol Neurosurg Psychiatry 2014; 85: 716–720. doi: 10.1136/jnnp-2013-306465. PMID: 24293000.
  41. Barbieri V., Cardinale F., Luoni A. et al. Risk factors for postoperative depression in 150 subjects treated for drug-resistant focal epilepsy. Epidemiol Psychiatr Sci 2011; 20: 99–105. doi: 10.1017/s2045796011000175. PMID: 21657120.
  42. Britton J.W., Shih J.J. Antiepileptic drugs and suicidality. Drug Healthc Patient Saf 2010; 2: 181–189. doi: 10.2147/dhps.s13225. PMID: 21701630.
  43. Preventing suicide: a global imperative. Geneva; 2014.
  44. Kalinin V.V. [Correction of affective and cognitive disorders in patients with epilepsy and the importance of lamotrigine]. Nevrologiya, neyropsikhiatriya, psikhosomatika 2013; 2: 78–83. (In Russ.)
  45. Olshanskaya A.S., Dyuzhakova A.V., Schneider N.A. et al. [Schimmelpinning–Feuerstein–Mims syndrome (description of the clinical case)]. Russkiy zhurnal detskoy nevrologii 2017; 12(3): 52–57. (In Russ.)
  46. Gandy M., Sharpe L., Perry K.N. Psychosocial predictors of depression and anxiety in patients with epilepsy: a systematic review. J Affect Disord 2012; 140: 222–232. doi: 10.1016/j.jad.2011.11.039. PMID: 22197509.
  47. Rai D., Kerr M.P., McManus S. et al. Epilepsy and psychiatric comorbidity: a nationally representative population-based study. Epilepsia 2012; 53: 1095–1103. doi: 10.1111/j.1528-1167.2012.03500.x. PMID: 22578079.

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Copyright (c) 2018 Narodova E.A., Schneider N.A., Narodov A.A., Dmitrenko D.V., Strotskaya I.G., Moskaleva P.V.

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