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The first clinical use of a Russian stent retriever during thrombectomy in patients with ischaemic stroke
- Authors: Grachev N.I.1, Malaev D.U.2, Andreev M.N.3, Trebushat D.V.3, Syrovnev G.I.3, Loskutnikov M.A.4, Vakin T.M.4, Konstantinov V.I.4, Domashenko M.A.4
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Affiliations:
- Primorsk Regional Clinical Hospital No. 1
- State Novosibirsk Regional Clinical Hospital
- Angioline Group, Koltsovo
- Central Clinical Health Unit
- Issue: Vol 15, No 1 (2021)
- Pages: 80-88
- Section: Technologies
- Submitted: 24.03.2021
- Published: 24.03.2021
- URL: https://annaly-nevrologii.com/journal/pathID/article/view/730
- DOI: https://doi.org/10.25692/ACEN.2021.1.10
- ID: 730
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Abstract
Introduction. Endovascular thrombectomy with stent retrievers (SR) is effectively used to treat patients with ischaemic stroke due to thrombotic occlusion of large intracerebral arteries.
The aim of the study was to evaluate the ability of popular SR made overseas to grab the blood clot in vitro compared with the first Russian SR (Grasper, Angioline), as well as to analyze the first use of this SR in clinical practice.
Materials and methods. A comparative assessment of different SR: Trevo ProVue (Stryker), Penumbra (Penumbra Inc.), Solitaire (Medtronic), and Grasper (Angioline) and their ability to capture a blood clot in vitro was performed. A clinical evaluation of the safety and efficacy of the Grasper SR in patients with ischaemic stroke was conducted.
Results. No difference was found in the ability of the test devices to pass through torturous areas, and all devices successfully reached the target implantation zone without difficulty. The clot could be removed entirely in all cases, with no evidence of fragmentation during removal. Clinical testing of the Grasper SR demonstrated that its performance was comparable to the Solitaire SR in restoring intracerebral blood flow.
Conclusion. The obtained results from the in vitro study demonstrate comparable effectiveness of the Russian SR to its counterparts. The clinical study results show that the Grasper SR can effectively and safely remove blood clots in clinical settings but requires further study on a larger number of subjects.
Keywords
About the authors
Nikita I. Grachev
Primorsk Regional Clinical Hospital No. 1
Email: mdomashenko@gmail.com
Россия, Vladivostok
Dastan U. Malaev
State Novosibirsk Regional Clinical Hospital
Email: mdomashenko@gmail.com
Россия, Novosibirsk
Mark N. Andreev
Angioline Group, Koltsovo
Email: mdomashenko@gmail.com
Россия, Novosibirsk region
Dmitry V. Trebushat
Angioline Group, Koltsovo
Email: mdomashenko@gmail.com
Россия, Novosibirsk region
Grigory I. Syrovnev
Angioline Group, Koltsovo
Email: mdomashenko@gmail.com
Россия, Novosibirsk region
Mark A. Loskutnikov
Central Clinical Health Unit
Email: mdomashenko@gmail.com
Россия, Magnitogorsk
Timofey M. Vakin
Central Clinical Health Unit
Email: mdomashenko@gmail.com
Россия, Magnitogorsk
Viktor I. Konstantinov
Central Clinical Health Unit
Email: mdomashenko@gmail.com
Россия, Magnitogorsk
Maksim A. Domashenko
Central Clinical Health Unit
Author for correspondence.
Email: mdomashenko@gmail.com
Россия, Magnitogorsk
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СМИ зарегистрировано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор).