The value of various brain pathways impairment in the post-stroke rehabilitation of walking function

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Corticospinal tract (CST) is the major brain pathway yielding motor activity; however, functional role of the CST and other pathways in the implementation of such a socially important function as walking in patients with stroke is not completely clear. Following the CST lesion the process of recovery involves not only CST on both sides but also other pathways, including the extrapyramidal tracts: corticoreticular (CRP) and corticorubrospinal (CRSP) pathways. With the help of modern neurovisualization methods we showed that Wallerian degeneration of the CST is not the only predictor of poor recovery of motor function after stroke, whereas a compensatory increase in fiber volume of CRP on the opposite side may improve recovery of affected leg. Further studies of the functional significance of brain pathways including the CRP and CRSP in the recovery of post-stroke walking function will clarify th mechanisms of neuroplasticity and predictors of recovery to optimize the personalized approach to rehabilitation.

About the authors

A. S. Kadykov

Research Center of Neurology, Russian Academy of Medical Sciences (Moscow)

Author for correspondence.
Russian Federation

Yu. D. Barkhatov

Research Center of Neurology, Russian Academy of Medical Sciences (Moscow)

Russian Federation


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Copyright (c) 2014 Kadykov A.S., Barkhatov Y.D.

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