Email this article 
Expression of Pgp in cells of neurovascular unit in perinatal hypoxic-ischemic brain injury
- Authors: Morgun A.V.1, Taranushenko T.E.1, Malinovskaya N.A.1, Okuneva O.S.1, Ustinova S.I.1, Karpova L.N.1, Salmina A.B.1, Pozhilenkova E.A.1, Laletin D.I.1, Frolova O.V.1, Reusheva N.V.1, Trufanova L.V.1
-
Affiliations:
- Krasnoyarsk State Medical University named after Professor V.F. Voino-Yasenetsky
- Issue: Vol 8, No 1 (2014)
- Pages: 40-43
- Section: Original articles
- Submitted: 01.02.2017
- Published: 09.02.2017
- URL: https://annaly-nevrologii.com/journal/pathID/article/view/192
- DOI: https://doi.org/10.17816/psaic192
- ID: 192
Cite item
Full Text
Abstract
We have studied peculiarities of P-glycoprotein (Pgp) expression on neuronal, astroglial and endothelial cells in newborn rats (P10) underwent perinatal hypoxic-ischemic brain damage. Expression of Pgp was markedly elevated in all the cells tested reaching the highest levels in astrocytes (4 hrs after injury) followed by increased levels in neuronal and endothelial cells (12 hrs after injury). The possible role of Pgp in pathogenesis of perinatal brain injury is discussed.
About the authors
A. V. Morgun
Krasnoyarsk State Medical University named after Professor V.F. Voino-Yasenetsky
Email: reg.kgmu@gmail.com
Россия, Krasnoyarsk
T. E. Taranushenko
Krasnoyarsk State Medical University named after Professor V.F. Voino-Yasenetsky
Email: reg.kgmu@gmail.com
Россия, Krasnoyarsk
N. A. Malinovskaya
Krasnoyarsk State Medical University named after Professor V.F. Voino-Yasenetsky
Email: reg.kgmu@gmail.com
Россия, Krasnoyarsk
O. S. Okuneva
Krasnoyarsk State Medical University named after Professor V.F. Voino-Yasenetsky
Email: reg.kgmu@gmail.com
Россия, Krasnoyarsk
S. I. Ustinova
Krasnoyarsk State Medical University named after Professor V.F. Voino-Yasenetsky
Email: reg.kgmu@gmail.com
Россия, Krasnoyarsk
L. N. Karpova
Krasnoyarsk State Medical University named after Professor V.F. Voino-Yasenetsky
Email: reg.kgmu@gmail.com
Россия, Krasnoyarsk
A. B. Salmina
Krasnoyarsk State Medical University named after Professor V.F. Voino-Yasenetsky
Email: reg.kgmu@gmail.com
Россия, Krasnoyarsk
E. A. Pozhilenkova
Krasnoyarsk State Medical University named after Professor V.F. Voino-Yasenetsky
Email: reg.kgmu@gmail.com
Россия, Krasnoyarsk
D. I. Laletin
Krasnoyarsk State Medical University named after Professor V.F. Voino-Yasenetsky
Email: reg.kgmu@gmail.com
Россия, Krasnoyarsk
O. V. Frolova
Krasnoyarsk State Medical University named after Professor V.F. Voino-Yasenetsky
Email: reg.kgmu@gmail.com
Россия, Krasnoyarsk
N. V. Reusheva
Krasnoyarsk State Medical University named after Professor V.F. Voino-Yasenetsky
Email: reg.kgmu@gmail.com
Россия, Krasnoyarsk
L. V. Trufanova
Krasnoyarsk State Medical University named after Professor V.F. Voino-Yasenetsky
Author for correspondence.
Email: reg.kgmu@gmail.com
Россия, Krasnoyarsk
References
- Андрианов А.В., Моргун А.В., Таранушенко Т.Е., Салмина А.Б. Значение маркеров прогрессии при остеосаркомах у детей. Сибирск. онкологич. журн. 2008; 5: 37–40.
- Демко И.В., Салмина А.Б., Моргун А.В., Малиновская Н.А. Экспрессия Р-гликопротеина на лимфоцитах периферической крови при тяжелых формах бронхиальной астмы и его роль в определении чувствительности к терапии глюкокортикостероидам. Пульмонол. 2007; 3: 41–46.
- Моргун А.В., Таранушенко Т.Е., Салмина А.Б. Значение уровня экспрессии Р-гликопротеина при остеосаркомах у детей. Врач-аспирант 2006; 15: 519–524.
- Chan H.S., Grogan T.M., Haddad G. et al. P-glycoprotein expression: Critical determinant in the response to osteosarcoma chemotherapy. J. Natl. Cancer Inst. 1997; 89: 1706–1715.
- Gaillard P.J., Van Der Sandt I.C., Voorwinden L.H. et al. Astrocytes increase the functional expression of P-glycoprotein in an in vitro model of the blood-brain barrier. Pharm. Res. 2000; 17 (10): 1198–1205.
- Kuhnke D., Jedlitschky G., Grube M. et al. MDR1-P-glycoprotein (ABCB1) mediates transport of Alzheimer’s amyloid-ОІ peptides — Implications for the mechanisms of Aβ clearance at the blood-brain barrier. Brain Pathol. 2007; 17 (4): 347–353.
- Putman M., van Veen H.W., Konings W.N. Molecular properties of bacterial multidrug transporters. Microbiol. Mol. Biol. Rev. 2000; 64: 672–693.
- Ronaldson P.T., Bendayan M., Gingras D. et al. Cellular localization and functional expression of P-glycoprotein in rat astrocyte cultures. J. Neurochem. 2004; 3: 788–800.
- Salmina A.B., Inzhutova A.I., Malinovskaya N.A., Petrova M.M. Endothelial dysfunctions аnd repair in Alzheimer-type neurodegeneration: neuronal and glial control. J. Alzheimers Dis. 2010; 22 (1): 17–36.
- Sarkadi B., Homolya L., Szakacs G., Varadi A. Human multidrug resistance ABCB and ABCG transporters: Participation in a chemoimmunity defense system. Physiol. Rev. 2006; 86: 1179–1236.
- Volka H.A., Burkhardt K., Potschka H. et al. Neuronal expression of the drug efflux transporter P-glycoprotein in the rat hippocampus after limbic seizures. Neurosci. 2004; 123 (3): 751–759.
Supplementary files
СМИ зарегистрировано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор).