Expression of Pgp in cells of neurovascular unit in perinatal hypoxic-ischemic brain injury

Cover Page

Abstract

We have studied peculiarities of P-glycoprotein (Pgp) expression on neuronal, astroglial and endothelial cells in newborn rats (P10) underwent perinatal hypoxic-ischemic brain damage. Expression of Pgp was markedly elevated in all the cells tested reaching the highest levels in astrocytes (4 hrs after injury) followed by increased levels in neuronal and endothelial cells (12 hrs after injury). The possible role of Pgp in pathogenesis of perinatal brain injury is discussed.

About the authors

A. V. Morgun

Krasnoyarsk State Medical University named after Professor V.F. Voino-Yasenetsky

Author for correspondence.
Email: platonova@neurology.ru
Russian Federation

T. E. Taranushenko

Krasnoyarsk State Medical University named after Professor V.F. Voino-Yasenetsky

Email: platonova@neurology.ru
Russian Federation

N. A. Malinovskaya

Krasnoyarsk State Medical University named after Professor V.F. Voino-Yasenetsky

Email: platonova@neurology.ru
Russian Federation

O. S. Okuneva

Krasnoyarsk State Medical University named after Professor V.F. Voino-Yasenetsky

Email: platonova@neurology.ru
Russian Federation

S. I. Ustinova

Krasnoyarsk State Medical University named after Professor V.F. Voino-Yasenetsky

Email: platonova@neurology.ru
Russian Federation

L. N. Karpova

Krasnoyarsk State Medical University named after Professor V.F. Voino-Yasenetsky

Email: platonova@neurology.ru
Russian Federation

A. B. Salmina

Krasnoyarsk State Medical University named after Professor V.F. Voino-Yasenetsky

Email: platonova@neurology.ru
Russian Federation

E. A. Pozhilenkova

Krasnoyarsk State Medical University named after Professor V.F. Voino-Yasenetsky

Email: platonova@neurology.ru
Russian Federation

D. I. Laletin

Krasnoyarsk State Medical University named after Professor V.F. Voino-Yasenetsky

Email: platonova@neurology.ru
Russian Federation

O. V. Frolova

Krasnoyarsk State Medical University named after Professor V.F. Voino-Yasenetsky

Email: platonova@neurology.ru
Russian Federation

N. V. Reusheva

Krasnoyarsk State Medical University named after Professor V.F. Voino-Yasenetsky

Email: platonova@neurology.ru
Russian Federation

L. V. Trufanova

Krasnoyarsk State Medical University named after Professor V.F. Voino-Yasenetsky

Email: platonova@neurology.ru
Russian Federation

References

  1. Андрианов А.В., Моргун А.В., Таранушенко Т.Е., Салмина А.Б. Значение маркеров прогрессии при остеосаркомах у детей. Сибирск. онкологич. журн. 2008; 5: 37–40.
  2. Демко И.В., Салмина А.Б., Моргун А.В., Малиновская Н.А. Экспрессия Р-гликопротеина на лимфоцитах периферической крови при тяжелых формах бронхиальной астмы и его роль в определении чувствительности к терапии глюкокортикостероидам. Пульмонол. 2007; 3: 41–46.
  3. Моргун А.В., Таранушенко Т.Е., Салмина А.Б. Значение уровня экспрессии Р-гликопротеина при остеосаркомах у детей. Врач-аспирант 2006; 15: 519–524.
  4. Chan H.S., Grogan T.M., Haddad G. et al. P-glycoprotein expression: Critical determinant in the response to osteosarcoma chemotherapy. J. Natl. Cancer Inst. 1997; 89: 1706–1715.
  5. Gaillard P.J., Van Der Sandt I.C., Voorwinden L.H. et al. Astrocytes increase the functional expression of P-glycoprotein in an in vitro model of the blood-brain barrier. Pharm. Res. 2000; 17 (10): 1198–1205.
  6. Kuhnke D., Jedlitschky G., Grube M. et al. MDR1-P-glycoprotein (ABCB1) mediates transport of Alzheimer’s amyloid-ОІ peptides — Implications for the mechanisms of Aβ clearance at the blood-brain barrier. Brain Pathol. 2007; 17 (4): 347–353.
  7. Putman M., van Veen H.W., Konings W.N. Molecular properties of bacterial multidrug transporters. Microbiol. Mol. Biol. Rev. 2000; 64: 672–693.
  8. Ronaldson P.T., Bendayan M., Gingras D. et al. Cellular localization and functional expression of P-glycoprotein in rat astrocyte cultures. J. Neurochem. 2004; 3: 788–800.
  9. Salmina A.B., Inzhutova A.I., Malinovskaya N.A., Petrova M.M. Endothelial dysfunctions аnd repair in Alzheimer-type neurodegeneration: neuronal and glial control. J. Alzheimers Dis. 2010; 22 (1): 17–36.
  10. Sarkadi B., Homolya L., Szakacs G., Varadi A. Human multidrug resistance ABCB and ABCG transporters: Participation in a chemoimmunity defense system. Physiol. Rev. 2006; 86: 1179–1236.
  11. Volka H.A., Burkhardt K., Potschka H. et al. Neuronal expression of the drug efflux transporter P-glycoprotein in the rat hippocampus after limbic seizures. Neurosci. 2004; 123 (3): 751–759.

Statistics

Views

Abstract: 779

PDF (Russian): 537

Article Metrics

Metrics Loading ...

Dimensions

PlumX


Copyright (c) 2014 Morgun A.V., Taranushenko T.E., Malinovskaya N.A., Okuneva O.S., Ustinova S.I., Karpova L.N., Salmina A.B., Pozhilenkova E.A., Laletin D.I., Frolova O.V., Reusheva N.V., Trufanova L.V.

Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.

This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies