Features of in vitro, in silico and transgenic models of Alzheimer’s disease

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Abstract

The review examines the current in vitro, in silico and trangenic experimental models of Alzheimer’s disease, is widely used for comprehensive studies of the pathogenesis of chronic neurodegenerative process. The experimental model should have a constructive, face and predictive validity, i.e. it must be established based on the known mechanisms of the pathogenesis of the disease and to ensure the development of symptoms characteristic of the disease, the severity of the past shall be reduced by the action of pharmacological agents already tested. Noted that transgenic models have high face and proven constructive validity.

About the authors

V. V. Kolobov

Research Center of Neurology, Russian Academy of Medical Sciences

Author for correspondence.
Email: platonova@neurology.ru
Russian Federation

Z. I. Storozheva

Serbsky National Research Centre for Social and Forensic Psychiatry (Moscow)

Email: platonova@neurology.ru
Russian Federation

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