Oxidation of blood lipoproteins in patients with cerebrovascular diseases
- Authors: Fedorova T.N.1, Maksimova M.Y.2, Varakin Y.Y.1, Gornostaeva G.V.1, Logvinenko A.A.1, Gnedovskaya E.V.1, Suslina Z.A.3
-
Affiliations:
- Research Center of Neurology
- Research Center of Neurology, Moscow
- Research Centre of Neurology
- Issue: Vol 8, No 1 (2014)
- Pages: 30-33
- Section: Original articles
- Submitted: 01.02.2017
- Published: 09.02.2017
- URL: https://annaly-nevrologii.com/journal/pathID/article/view/194
- DOI: https://doi.org/10.17816/psaic194
- ID: 194
Cite item
Full Text
Abstract
An comparative analysis of oxidation of low density lipoproteins/verylow density lipoproteins, and a clinical severity of acute and chronic cerebrovascular diseases was performed. To assess the intensity of lipid peroxidation we estimated several kinetic parameters of ferrous iron-induced chemiluminescence.
In this article we present the results of the clinical and biochemical assessment of 412 patients with wide spectrum of cerebrovascular diseases, such as acute stroke (n=179), chronic cerebrovascular disease (n=105), hypertensive crisis (n=60), hypertension without cerebral symptoms (n=47), and initial stages of chronic cerebrovascular insufficiency (n=21). We showed that lipid oxidation becomes evident even on the early stages of cerebrovascular diseases, and then progresses gradually following clinical severity of the disease, and the intensity of the peroxidation rises significantly in chronic and acute forms of cerebrovascular diseases.
About the authors
Tatiana N. Fedorova
Research Center of Neurology
Author for correspondence.
Email: tnf51@bk.ru
Russian Federation, Moscow
Marina Yu. Maksimova
Research Center of Neurology, Moscow
Email: tnf51@bk.ru
ORCID iD: 0000-0002-7682-6672
Russian Federation, Moscow, Volokolamskoe shosse,80
Yu. Ya. Varakin
Research Center of Neurology
Email: tnf51@bk.ru
Russian Federation, Moscow
G. V. Gornostaeva
Research Center of Neurology
Email: tnf51@bk.ru
Russian Federation, Moscow
A. A. Logvinenko
Research Center of Neurology
Email: tnf51@bk.ru
Russian Federation, Moscow
Elena V. Gnedovskaya
Research Center of Neurology
Email: tnf51@bk.ru
Russian Federation, Moscow
Z. A. Suslina
Research Centre of Neurology
Email: tnf51@bk.ru
Russian Federation, Moscow
References
- Болдырев А.А. Окислительный стресс и мозг. Соросовский образовательный журнал 2001; 7, 4: 21–28.
- Верещагин Н.В., Моргунов В.А., Гулевская Т.С. Патология головного мозга при атеросклерозе и артериальной гипертонии. М.: Медицина, 1997: 288.
- Ланкин В.З., Вихерт А.М., Тихазе А.К. Роль перекисного окисления липидов в этиологии и патогенезе атеросклероза. Вопросы медицинской химии 1985; 3: 18–24.
- Суслина З.А., Максимова М.Ю., Федорова Т.Н. Оксидантный стресс и основные направления нейропротекции при нарушениях мозгового кровообращения. Неврол. журн. 2007; 4: 4–8.
- Федорова Т.Н. Окислительный стресс и защита головного мозга от ишемического повреждения. Автореф. дисс. докт. б.наук. М., 2004; 40.
- Atlante A., Calissano P., Bobba A. et al. Glutamate neurotoxicity,oxidative stress and mitochondria. FEBS Lett. 2001; 497: 1–5.
- Green D.R. and Reed J.C. Mitochondria and apoptosis. Science 1998; 281: 1309–1312.
- Harrison D.G., Gongora M.C., Guzik T.J., Widder J. Oxidative stress and hypertension. J. Am. Soc. Hypertens. 2003; 1: 30–44.
- Madamanchi N.R. and Runge M.S. Mitochondrial dysfunction in atherosclerosis. Circ. Res. 2007; 100: 460–473.
- Ohachi M., Runge M.S., Faraci F.M., Heistad D.D. MnSOD deficiency increases endothelial dysfunction in ApoE-deficient mice. Arterioscler. Thromb. Vasc. Biol. 2006; 26: 2331–2336.
- Ross R. Atherosclerosis- an inflammatory disease. N. Engl. J. Med. 1999; 340: 115–126.
- Siesjo B.K., Zhao Q., PahlmarkK. et al. Glutamate, calcium and free radicals as mediators of ischemic brain damage. Ann. Thorac. Surg. 1995; 59:1316 –1320.
- Victor V.M., Apostolova N., Herance R. et al. Oxidative stress and mitochondrial dysfunction in atherosclerosis: mitochondria-targeted antioxidants as potential therapy. Curr. Med. Chem. 2009; 16: 4654–4667.
- Vladimirov Y.A. Studies of antioxidant activity by measuring chemiluminescence kinetics, In Natural Antioxidants: Molecular Mechanisms and Health Effects (L. Packer, M.G. Traber and W. Xin, Eds.), AOCS Press, Champaign, Il., 1996; 125–144.
- Warner D.S., Sheng H., Batini-Haberle I. Oxidants, antioxidants and the ischemic brain. J. of Exp. Biol. 2004; 207: 3221–3231.