Oxidation of blood lipoproteins in patients with cerebrovascular diseases

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Abstract

An comparative analysis of oxidation of low density lipoproteins/verylow density lipoproteins, and a clinical severity of acute and chronic cerebrovascular diseases was performed. To assess the intensity of lipid peroxidation we estimated several kinetic parameters of ferrous iron-induced chemiluminescence.
In this article we present the results of the clinical and biochemical assessment of 412 patients with wide spectrum of cerebrovascular diseases, such as acute stroke (n=179), chronic cerebrovascular disease (n=105), hypertensive crisis (n=60), hypertension without cerebral symptoms (n=47), and initial stages of chronic cerebrovascular insufficiency (n=21). We showed that lipid oxidation becomes evident even on the early stages of cerebrovascular diseases, and then progresses gradually following clinical severity of the disease, and the intensity of the peroxidation rises significantly in chronic and acute forms of cerebrovascular diseases.

About the authors

T. N. Fedorova

Research Center of Neurology, Russian Academy of Medical Sciences (Moscow)

Author for correspondence.
Email: platonova@neurology.ru
Russian Federation

M. Yu. Maksimova

Research Center of Neurology, Russian Academy of Medical Sciences (Moscow)

Email: platonova@neurology.ru
Russian Federation

Yu. Ya. Varakin

Research Center of Neurology, Russian Academy of Medical Sciences (Moscow)

Email: platonova@neurology.ru
Russian Federation

G. V. Gornostaeva

Research Center of Neurology, Russian Academy of Medical Sciences (Moscow)

Email: platonova@neurology.ru
Russian Federation

A. A. Logvinenko

Research Center of Neurology, Russian Academy of Medical Sciences (Moscow)

Email: platonova@neurology.ru
Russian Federation

E. V. Gnedovskaya

Research Center of Neurology, Russian Academy of Medical Sciences (Moscow)

Email: platonova@neurology.ru
Russian Federation

Z. A. Suslina

Research Center of Neurology, Russian Academy of Medical Sciences (Moscow)

Email: platonova@neurology.ru
Russian Federation

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Copyright (c) 2014 Fedorova T.N., Maksimova M.Y., Varakin Y.Y., Gornostaeva G.V., Logvinenko A.A., Gnedovskaya E.V., Suslina Z.A.

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