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Oxidation of blood lipoproteins in patients with cerebrovascular diseases
- Authors: Fedorova T.N.1, Maksimova M.Y.2, Varakin Y.Y.1, Gornostaeva G.V.1, Logvinenko A.A.1, Gnedovskaya E.V.1, Suslina Z.A.3
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Affiliations:
- Research Center of Neurology
- Research Center of Neurology, Moscow
- Research Centre of Neurology
- Issue: Vol 8, No 1 (2014)
- Pages: 30-33
- Section: Original articles
- URL: https://annaly-nevrologii.com/journal/pathID/article/view/194
- DOI: https://doi.org/10.17816/psaic194
- ID: 194
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Abstract
An comparative analysis of oxidation of low density lipoproteins/verylow density lipoproteins, and a clinical severity of acute and chronic cerebrovascular diseases was performed. To assess the intensity of lipid peroxidation we estimated several kinetic parameters of ferrous iron-induced chemiluminescence.
In this article we present the results of the clinical and biochemical assessment of 412 patients with wide spectrum of cerebrovascular diseases, such as acute stroke (n=179), chronic cerebrovascular disease (n=105), hypertensive crisis (n=60), hypertension without cerebral symptoms (n=47), and initial stages of chronic cerebrovascular insufficiency (n=21). We showed that lipid oxidation becomes evident even on the early stages of cerebrovascular diseases, and then progresses gradually following clinical severity of the disease, and the intensity of the peroxidation rises significantly in chronic and acute forms of cerebrovascular diseases.
About the authors
Tatiana N. Fedorova
Research Center of Neurology
Author for correspondence.
Email: tnf51@bk.ru
Russian Federation, Moscow
Marina Yu. Maksimova
Research Center of Neurology, Moscow
Email: tnf51@bk.ru
ORCID iD: 0000-0002-7682-6672
Russian Federation, Moscow, Volokolamskoe shosse,80
Yu. Ya. Varakin
Research Center of Neurology
Email: tnf51@bk.ru
Russian Federation, Moscow
G. V. Gornostaeva
Research Center of Neurology
Email: tnf51@bk.ru
Russian Federation, Moscow
A. A. Logvinenko
Research Center of Neurology
Email: tnf51@bk.ru
Russian Federation, Moscow
Elena V. Gnedovskaya
Research Center of Neurology
Email: tnf51@bk.ru
Russian Federation, Moscow
Z. A. Suslina
Research Centre of Neurology
Email: tnf51@bk.ru
Russian Federation, Moscow
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СМИ зарегистрировано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор).