We present results of clinical and electrophysological analysis of 34 patients with recurrent facial neuropathy (rFN). Its frequency (10.9%) among all forms of facial neuropathies was determined, and clinical and EMG characteristics, as well as possible risk factors, were described. A separate group of familial rFN was identified, and these patients exhibited high percentage of subclinical peripheral nerve involvement. Positive family history, presence of relapses and electroneurographic features allowed to suspect hereditary neuropathy with liability to pressure palsy in these patients. However, molecular analysis of the РМР22 gene failed to reveal a typical gene deletion. These results leave open the question about etiology and pathophysiologic mechanisms of rFN and warrant further studies of genetic defect underlying a familial form of rFN.
Recurrent facial nerve neuropathies: clinical, electrophysiological and molecular analysis
- Authors: Savitskaya N.G.1, Nikitin S.S.2,3, Illarioshkin S.N.1, Klyushnikov S.A.1, Ivanova-Smolenskaya I.A.1, Ostaphyichuk A.V.4
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Affiliations:
- Research Center of Neurology
- Regional public organization “Association for Neuromuscular Diseases”
- Clinics “Practical Neurology”
- Central military hospital № 5, Ministry of Defense of Russian Federation
- Issue: Vol 5, No 4 (2011)
- Pages: 29-32
- Section: Original articles
- Submitted: 03.02.2017
- Published: 13.02.2017
- URL: https://annaly-nevrologii.com/journal/pathID/article/view/291
- DOI: https://doi.org/10.17816/psaic291
- ID: 291
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About the authors
N. G. Savitskaya
Research Center of Neurology
Email: elirom@mail.ru
Russian Federation, Moscow
Sergey S. Nikitin
Regional public organization “Association for Neuromuscular Diseases”; Clinics “Practical Neurology”
Email: elirom@mail.ru
Russian Federation, Moscow
Sergey N. Illarioshkin
Research Center of Neurology
Email: elirom@mail.ru
ORCID iD: 0000-0002-2704-6282
D. Sci. (Med.), Prof., RAS Full Member, Deputy Director for Science; Director, Brain Institute
Russian Federation, 125367, Moscow, Volokolamskoye shosse, 80Sergey A. Klyushnikov
Research Center of Neurology
Email: elirom@mail.ru
Russian Federation, Moscow
I. A. Ivanova-Smolenskaya
Research Center of Neurology
Author for correspondence.
Email: elirom@mail.ru
Russian Federation, Moscow
A. V. Ostaphyichuk
Central military hospital № 5, Ministry of Defense of Russian Federation
Email: elirom@mail.ru
Russian Federation, Кrasnogorsk
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