Recurrent facial nerve neuropathies: clinical, electrophysiological and molecular analysis

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Abstract

We present results of clinical and electrophysological analysis of 34 patients with recurrent facial neuropathy (rFN). Its frequency (10.9%) among all forms of facial neuropathies was determined, and clinical and EMG characteristics, as well as possible risk factors, were described. A separate group of familial rFN was identified, and these patients exhibited high percentage of subclinical peripheral nerve involvement. Positive family history, presence of relapses and electroneurographic features allowed to suspect hereditary neuropathy with liability to pressure palsy in these patients. However, molecular analysis of the РМР22 gene failed to reveal a typical gene deletion. These results leave open the question about etiology and pathophysiologic mechanisms of rFN and warrant further studies of genetic defect underlying a familial form of rFN.

 
 

About the authors

N. G. Savitskaya

Research Center of Neurology

Email: elirom@mail.ru
Россия, Moscow

Sergey S. Nikitin

Regional public organization “Association for Neuromuscular Diseases”; Clinics “Practical Neurology”

Email: elirom@mail.ru
Россия, Moscow

Sergey N. Illarioshkin

Research Center of Neurology

Email: elirom@mail.ru
ORCID iD: 0000-0002-2704-6282

D. Sci. (Med.), Prof., RAS Full Member, Deputy Director for Science; Director, Brain Institute

Россия, 125367, Moscow, Volokolamskoye shosse, 80

Sergey A. Klyushnikov

Research Center of Neurology

Email: elirom@mail.ru

 

Россия, Moscow

I. A. Ivanova-Smolenskaya

Research Center of Neurology

Author for correspondence.
Email: elirom@mail.ru
Россия, Moscow

A. V. Ostaphyichuk

Central military hospital № 5, Ministry of Defense of Russian Federation

Email: elirom@mail.ru
Россия, Кrasnogorsk

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Copyright (c) 2011 Savitskaya N.G., Nikitin S.S., Illarioshkin S.N., Klushnikov S.A., Ivanova-Smolenskaya I.A., Ostaphyichuk A.V.

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