The course of the acute period of ischemic stroke after inravenous thrombolysis

Cover Page

Cite item

Full Text


Intravenous (i.v.) thrombolytic therapy of acute ischemic stroke is highly effective in selected group of patients. The most common complications of systemic thrombolysis are intracerebral haematomas, allergic reactions and acute hypotension. The early reocclusion/rethrombosis of intracranial arteries also may influency the efficacy of thrombolysis. The clinical cases of allergic reactions, acute hypotension and early reocclusion in the first 24 hours after i.v. thrombolysis are described in the article. It is concluded that monitoring of neurological status and haemodynamic parameters during and 24 hours after i.v. thrombolysis are the important factors of good outcome.


About the authors

M. A. Domashenko

Research Center of Neurology

Russian Federation, Moscow

Marina Yu. Maksimova

Research Center of Neurology, Moscow

ORCID iD: 0000-0002-7682-6672
Russian Federation, Moscow, Volokolamskoe shosse,80

M. A. Loskutnikov

Research Center of Neurology

Russian Federation, Moscow

Alexey A. Nikonov

Research Center of Neurology

ORCID iD: 0000-0003-4934-1423

Cand. Sci. (Med.), neurologist, 2nd Neurological department, Institute of Clinical and Preventive Neurology

Russian Federation, Moscow

V. V. Bryukhov

Research Center of Neurology

Author for correspondence.
Russian Federation, Moscow


  1. Пирадов М.А. Интенсивная терапия инсульта: взгляд на проблему. Анналы клинической и экспериментальной неврологии 2007; 1: 17–22.
  2. Adams H. et al. Guidelines for the management of adults with ischemic stroke. Stroke 2007; 38: 1655–1711.
  3. Ahmed N. et al. Implementation and outcome of thrombolysis with alteplase 3-4.5 h after an acute stroke: an updated analysis from SITSISTR. Lancet Neurology 2010; 9: 866–874.
  4. Alexandrov A.V., Grotta J.C. Arterial reocclusion in stroke patients treated with intravenous tissue plasminogen activator. Neurology 2002, 59 (6): 862–867.
  5. Guidelines for Management of Ischaemic Stroke of the European Stroke Organisation, 2008.
  6. Lansberg M.G. et al. Risk factors of symptomatic intracerebral hemorrhage after tPA therapy for acute stroke. Stroke 2007; 38: 2275–2278.
  7. Wardlaw C., Wardlaw J. Therapeutic thrombolysis for acute ischaemic stroke. BMJ, 2003 (1); 326 (7383): 233–234.

Supplementary files

Supplementary Files

Copyright (c) 2011 Domashenko M.A., Maksimova M.Y., Loskutnikov M.A., Nikonov A.A., Bryukhov V.V.

Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.

СМИ зарегистрировано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор).
Регистрационный номер и дата принятия решения о регистрации СМИ: серия ПИ № ФС 77-83204 от 12.05.2022.

This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies