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Intravenous (i.v.) thrombolytic therapy of acute ischemic stroke is highly effective in selected group of patients. The most common complications of systemic thrombolysis are intracerebral haematomas, allergic reactions and acute hypotension. The early reocclusion/rethrombosis of intracranial arteries also may influency the efficacy of thrombolysis. The clinical cases of allergic reactions, acute hypotension and early reocclusion in the first 24 hours after i.v. thrombolysis are described in the article. It is concluded that monitoring of neurological status and haemodynamic parameters during and 24 hours after i.v. thrombolysis are the important factors of good outcome.
The course of the acute period of ischemic stroke after inravenous thrombolysis
- Authors: Domashenko M.A.1, Maksimova M.Y.2, Loskutnikov M.A.1, Nikonov A.A.1, Bryukhov V.V.1
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Affiliations:
- Research Center of Neurology
- Research Center of Neurology, Moscow
- Issue: Vol 5, No 1 (2011)
- Pages: 52-57
- Section: Clinical analysis
- URL: https://annaly-nevrologii.com/journal/pathID/article/view/313
- DOI: https://doi.org/10.17816/psaic313
- ID: 313
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About the authors
M. A. Domashenko
Research Center of Neurology
Email: mdomashenko@gmail.com
Russian Federation, Moscow
Marina Yu. Maksimova
Research Center of Neurology, Moscow
Email: mdomashenko@gmail.com
ORCID iD: 0000-0002-7682-6672
Russian Federation, Moscow, Volokolamskoe shosse,80
M. A. Loskutnikov
Research Center of Neurology
Email: mdomashenko@gmail.com
Russian Federation, Moscow
Alexey A. Nikonov
Research Center of Neurology
Email: mdomashenko@gmail.com
ORCID iD: 0000-0003-4934-1423
Cand. Sci. (Med.), neurologist, 2nd Neurological department, Institute of Clinical and Preventive Neurology
Russian Federation, MoscowV. V. Bryukhov
Research Center of Neurology
Author for correspondence.
Email: mdomashenko@gmail.com
Russian Federation, Moscow
References
- Пирадов М.А. Интенсивная терапия инсульта: взгляд на проблему. Анналы клинической и экспериментальной неврологии 2007; 1: 17–22.
- Adams H. et al. Guidelines for the management of adults with ischemic stroke. Stroke 2007; 38: 1655–1711.
- Ahmed N. et al. Implementation and outcome of thrombolysis with alteplase 3-4.5 h after an acute stroke: an updated analysis from SITSISTR. Lancet Neurology 2010; 9: 866–874.
- Alexandrov A.V., Grotta J.C. Arterial reocclusion in stroke patients treated with intravenous tissue plasminogen activator. Neurology 2002, 59 (6): 862–867.
- Guidelines for Management of Ischaemic Stroke of the European Stroke Organisation, 2008. http://www.eso-stroke.org/recommendations
- Lansberg M.G. et al. Risk factors of symptomatic intracerebral hemorrhage after tPA therapy for acute stroke. Stroke 2007; 38: 2275–2278.
- Wardlaw C., Wardlaw J. Therapeutic thrombolysis for acute ischaemic stroke. BMJ, 2003 (1); 326 (7383): 233–234.
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