The course of the acute period of ischemic stroke after inravenous thrombolysis

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Abstract

Intravenous (i.v.) thrombolytic therapy of acute ischemic stroke is highly effective in selected group of patients. The most common complications of systemic thrombolysis are intracerebral haematomas, allergic reactions and acute hypotension. The early reocclusion/rethrombosis of intracranial arteries also may influency the efficacy of thrombolysis. The clinical cases of allergic reactions, acute hypotension and early reocclusion in the first 24 hours after i.v. thrombolysis are described in the article. It is concluded that monitoring of neurological status and haemodynamic parameters during and 24 hours after i.v. thrombolysis are the important factors of good outcome.

 

About the authors

M. A. Domashenko

Research Center of Neurology

Email: mdomashenko@gmail.com
Россия, Moscow

Marina Yu. Maksimova

Research Center of Neurology, Moscow

Email: mdomashenko@gmail.com
ORCID iD: 0000-0002-7682-6672
Россия, Moscow, Volokolamskoe shosse,80

M. A. Loskutnikov

Research Center of Neurology

Email: mdomashenko@gmail.com
Россия, Moscow

Alexey A. Nikonov

Research Center of Neurology

Email: mdomashenko@gmail.com
ORCID iD: 0000-0003-4934-1423

Cand. Sci. (Med.), neurologist, 2nd Neurological department, Institute of Clinical and Preventive Neurology

Россия, Moscow

V. V. Bryukhov

Research Center of Neurology

Author for correspondence.
Email: mdomashenko@gmail.com
Россия, Moscow

References

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  2. Adams H. et al. Guidelines for the management of adults with ischemic stroke. Stroke 2007; 38: 1655–1711.
  3. Ahmed N. et al. Implementation and outcome of thrombolysis with alteplase 3-4.5 h after an acute stroke: an updated analysis from SITSISTR. Lancet Neurology 2010; 9: 866–874.
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  5. Guidelines for Management of Ischaemic Stroke of the European Stroke Organisation, 2008. http://www.eso-stroke.org/recommendations
  6. Lansberg M.G. et al. Risk factors of symptomatic intracerebral hemorrhage after tPA therapy for acute stroke. Stroke 2007; 38: 2275–2278.
  7. Wardlaw C., Wardlaw J. Therapeutic thrombolysis for acute ischaemic stroke. BMJ, 2003 (1); 326 (7383): 233–234.

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Copyright (c) 2011 Domashenko M.A., Maksimova M.Y., Loskutnikov M.A., Nikonov A.A., Bryukhov V.V.

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