Mitochondrial arteriopathy, a suspected cause of spontaneous dissection of the internal carotid and vertebral arteries

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Abstract

Dissection of the internal carotid artery and vertebral artery (ICA/VA) is one of the leading causes of ischaemic stroke in young people. The reason for the arterial wall weakness leading to its dissection remains unclear. Morphological study of the ICA/VA, and clinical data, indicate the presence of connective tissue dysplasia in patients, which is not associated with any known hereditary diseases.

In this article, the authors summarize the results of their studies (histological and histochemical examination of muscle biopsies, electron microscopy of skin arteries) and observations (stroke-like episode, A3243G mutation in the mitochondrial genome in a patient with repeat ICA/VA dissections; increased peak lactate during MR spectroscopy in a patient who suffered an ICA dissection, then lobar hemorrhages a few years later). Based on these, the authors propose mitochondrial arteriopathy as the cause of arterial wall dysplasia leading to dissection. This article provides data on the presence of mitochondrial disorders in patients with ICA/VA dissection.

About the authors

Ludmila A. Kalashnikova

Research Center of Neurology

Author for correspondence.
Email: kalashnikovancn@yandex.ru
Россия, Moscow

Alla V. Sakharova

Research Center of Neurology

Email: kalashnikovancn@yandex.ru
Россия, Moscow

Roksana P. Chaikovskaya

Research Center of Neurology

Email: kalashnikovancn@yandex.ru
Россия, Moscow

Larisa A. Dobrynina

Research Center of Neurology

Email: kalashnikovancn@yandex.ru
Россия, Moscow

Tat'yana S. Gulevskaya

Research Center of Neurology

Email: kalashnikovancn@yandex.ru
Россия, Moscow

Mariia V. Gubanova

Research Center of Neurology

Email: kalashnikovancn@yandex.ru
Россия, Moscow

Anastasiya S. Voronkova

Research Center of Neurology

Email: kalashnikovancn@yandex.ru
Россия, Moscow

Vladimir S. Sukhorukov

Research Center of Neurology

Email: kalashnikovancn@yandex.ru
Россия, Moscow

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Copyright (c) 2021 Kalashnikova L.A., Sakharova A.V., Chaikovskaya R.P., Dobrynina L.A., Gulevskaya T.S., Gubanova M.V., Voronkova A.S., Sukhorukov V.S.

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